Welcome to the international website of WJOG!
We are constantly exploring new research opportunities.

Message from the Chairman

The West Japan Oncology Group (WJOG; the Group) was established in 2000 to conduct clinical studies on lung cancer. Since then, WJOG has added a gastrointestinal cancer group in 2007 and a breast cancer group in 2009. In 2021, the Group established a basket group to conduct clinical studies based on cross-organ biomarkers. Under the leadership of the individual group head, each group actively drafts and implements clinical studies. As of January 2026, WJOG has grown to become one of Japan's largest clinical study groups conducting 41 clinical studies with the participation of 389 facilities in Japan. Its findings have been published in prominent journals and shared with international academic societies. In recent years, the scope of the WJOG activities has broadened to include the collection of real-world data on cancer, the training of young researchers, and active cooperation with cancer patients through patient and public involvement (PPI) and other initiatives, in addition to clinical studies.

Specifically, the WJOG collects prospective real-world data on thousands of lung cancer patients, which the Group plans to make available for flexible use through activities that include joint research with corporate and other partners. With regard to cooperation with patient organizations, WJOG has been a member of the Global Lung Cancer Coalition for many years and is conducting clinical research proposed by a patient organization on the subject of EGFR-mutant lung cancer (Takeda M, et al: Lung Cancer 2023 and 2024). The three groups on lung cancer, gastrointestinal cancer, and breast cancer have established the WING, FLAG, and BLIGHT groups of young researchers, each with dozens of members, which are actively proposing clinical studies. The FLAG group also meets with the German clinical testing group AIO.

While the WJOG successively publishes the results of clinical studies through academic societies, English-language papers, and other means, most of its other activities are not widely known outside of Japan. Traditionally, research on cancer examinations and treatment consisted mainly of global joint research because of the considerable resources required. The WJOG has decided to open an English-language website to more actively promote global collaboration to let people around the world become more aware of its activities.

The WJOG appreciates your continued support.

Nobuyuki Yamamoto
Chairman, WJOG Nobuyuki Yamamoto

About WJOG

WJOG is a leading multi-institutional clinical trial group in Japan.

WJOG is a certified non-profit organization (NPO) in Japan dedicated to advanced cancer treatment and clinical research. WJOG has four groups: Thoracic Oncology Group, Gastrointestinal Oncology Group, Breast Oncology Group, and Basket Trial Committee.

  • Thoracic Oncology Group Thoracic
    Oncology Group
  • Gastrointestinal Oncology Group Gastrointestinal
    Oncology Group
  • Breast Oncology Group Breast
    Oncology Group
  • Basket Trial Committee Basket Trial
    Committee

Directors

  • Chairman

  • Vice Chairman

  • Nobuyuki Yamamoto

    Chairman

    Wakayama Medical University Hospital
  • Narikazu Boku

    Vice Chairman

    The University of Tokyo Institute of Medical Science Hospital
  • Koji Takeda
    West Japan Oncology Group
  • Executive Director

  • Hirotsugu Kenmotsu

    Executive Director

    Shizuoka Cancer Center
  • Kei Muro
    Aichi Cancer Center
  • Toshimi Takano
    Cancer Institute Hospital of JFCR
  • Hidetoshi Hayashi
    Kindai University Faculty of Medicine
  • Kentaro Yamazaki
    Shizuoka Cancer Center
  • Satoru Miura
    Miura Clinic
  • Naoki Ishizuka
    Kyoto University Graduate School of Medicine
  • Isamu Okamoto
    Kyushu University Hospital

WJOG by the Numbers

Comprising members from diverse professionals, including doctors, nurses, and pharmacists, WJOG operates as a collaborative effort. The organization fosters an interdisciplinary approach to cancer care, leveraging the expertise of professionals from various fields.
  • Founded
    in
    1991
  • Total enrolled
    patients(2000-2025)
    26,864
  • Active
    Clinical Trials
    41
  • Participating
    Institutions
    389
  • Active
    WJOG Members
    958

2026.02.08 update

Key Clinical Trials

We have many more clinical trials in progress, and we are constantly exploring new research opportunities.

Study Group Study Number Study Type Study Title Clinical Trials Registry
Thoracic WJOG20924L
(J-OLIGO)
Phase III study of multidisciplinary therapy combined local ablative therapy with immune-checkpoint inhibitors for patients with synchronous oligometastatic NSCLC (J-OLIGO: WJOG20924L) jRCTs041250114
Gastrointestinal WJOG19524G A Phase II Clinical Trial Evaluating the Antiemetic Effect and Safety of a Five-Drug Combination Therapy for Zolbetuximab, Including Olanzapine and Antihistamines, with or without Pre-Treatment Olanzapine (OPTIMIZE:WJOG19524G) jRCTs041250124
Breast WJOG18123B
(SAKURA)
WJOG18123B: Randomized placebo-controlled study of S-equol containing supplement for the control of aromatase inhibitor-induced musculoskeletal pain and stiffness in hands (SAKURA) jRCTs031240754
Basket WJOG15221M
(ALLBREAK)
A multicenter phase II study of brigatinib for patients with ALK fusion genes positive metastatic solid tumor (WJOG15221M/ XB99036) jRCT2041210148

Our Publications

WJOG has conducted many clinical trials. For more information, please click the button below.

Collaboration Process with WJOG

For Academic and Industry Partners

  1. Initial Inquiry

    Initial Inquiry

    Contact the Investigators or use the "contact us".

    (Submission of a research idea or collaboration proposal)

  2. Preliminary Discussion

    Preliminary Discussion

    Conceptual Discussion at the WJOG Advisory Meeting

    (Scientific rationale, feasibility, collaboration framework, and alignment with WJOG mission)

  3. Concept Review

    Concept Review

    Review by the WJOG Executive Board

    (Decision to proceed to protocol development)

  4. Protocol Development

    Protocol Development

    Detailed Study Planning

    (Study design, endpoints, operational feasibility, roles and responsibilities)

  5. Final Approval & Study Initiation

    Final Approval & Study Initiation

    Protocol Approval and Study Launch

    (Approval by the WJOG Executive Board and institutional IRB review)

WJOG conducts investigator-initiated clinical trials through a structured and transparent governance process. We welcome collaboration proposals from both academic investigators and industry partners, and encourage early discussions to explore scientifically meaningful and feasible research opportunities.

All studies are conducted in compliance with ethical guidelines and ICH-GCP.

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